Building biological memory by linking positive feedback loops.

@article{Chang2010BuildingBM,
  title={Building biological memory by linking positive feedback loops.},
  author={Dong-Eun Chang and Shelly Kin Shan Leung and Mariette R. Atkinson and Aaron N Reifler and Daniel B. Forger and Alexander J. Ninfa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 1},
  pages={
          175-80
        }
}
A common topology found in many bistable genetic systems is two interacting positive feedback loops. Here we explore how this relatively simple topology can allow bistability over a large range of cellular conditions. On the basis of theoretical arguments, we predict that nonlinear interactions between two positive feedback loops can produce an ultrasensitive response that increases the range of cellular conditions at which bistability is observed. This prediction was experimentally tested by… CONTINUE READING
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