Building a successful structural motif into sialylmimetics-cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties.

@article{Streicher2006BuildingAS,
  title={Building a successful structural motif into sialylmimetics-cyclohexenephosphonate monoesters as pseudo-sialosides with promising inhibitory properties.},
  author={Hansj{\"o}rg Streicher and H. G. Busse},
  journal={Bioorganic & medicinal chemistry},
  year={2006},
  volume={14 4},
  pages={1047-57}
}
A variable synthesis of a new class of sialylmimetics which provides access to pseudo-sialosides containing the successful cyclohexene motif in the sialic acid mimicking part has been developed. The D- and L-xylo cyclohexenephosphonate scaffolds allow attachment of selected aglycons or aglycon mimetics via mixed phosphonate diester strategies and some… CONTINUE READING