Building a structured model of a complex pharmacokinetic system with time delays.

@article{Durisov1995BuildingAS,
  title={Building a structured model of a complex pharmacokinetic system with time delays.},
  author={M{\'a}ria Durisov{\'a} and Ladislav Ded{\'i}k and Mouna Balan},
  journal={Bulletin of mathematical biology},
  year={1995},
  volume={57 6},
  pages={787-808}
}
This paper presents a description of the procedure for building a structured model of a complex pharmacokinetic system on using its transfer function. The example employed is that of the pharmacokinetic system based on gentamicin plasma concentrations after intravenous and intratracheal administration to guinea pigs, describing the pathway of the drug into the systemic circulation after the extravascular injection mentioned. The structured model selected consisted of a submodel of a… CONTINUE READING

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