Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme.

@article{Alley2001BuildingAR,
  title={Building a replisome solution structure by elucidation of protein-protein interactions in the bacteriophage T4 DNA polymerase holoenzyme.},
  author={Stephen C. Alley and Michael A Trakselis and Milena Mayer and Faoud T Ishmael and A. Daniel Jones and Stephen J Benkovic},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 42},
  pages={39340-9}
}
Assembly of DNA replication systems requires the coordinated actions of many proteins. The multiprotein complexes formed as intermediates on the pathway to the final DNA polymerase holoenzyme have been shown to have distinct structures relative to the ground-state structures of the individual proteins. By using a variety of solution-phase techniques, we have elucidated additional information about the solution structure of the bacteriophage T4 holoenzyme. Photocross-linking and mass… CONTINUE READING

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