Building a lineage from single cells: genetic techniques for cell lineage tracking

@article{Woodworth2017BuildingAL,
  title={Building a lineage from single cells: genetic techniques for cell lineage tracking},
  author={Mollie B Woodworth and Kelly M. Girskis and Christopher A. Walsh},
  journal={Nature Reviews Genetics},
  year={2017},
  volume={18},
  pages={230-244}
}
Resolving lineage relationships between cells in an organism is a fundamental interest of developmental biology. Furthermore, investigating lineage can drive understanding of pathological states, including cancer, as well as understanding of developmental pathways that are amenable to manipulation by directed differentiation. Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of methodological advances in exogenous… CONTINUE READING
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