Building a fission machine--structural insights into dynamin assembly and activation.

@article{Chappie2013BuildingAF,
  title={Building a fission machine--structural insights into dynamin assembly and activation.},
  author={Joshua S Chappie and Fred Dyda},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 13},
  pages={2773-84}
}
Dynamin is a large multidomain GTPase that assembles into helical arrays around the necks of deeply invaginated clathrin-coated pits and catalyzes membrane fission during the final stages of endocytosis. Although it is well established that the function of dynamin in vivo depends on its oligomerization and its capacity for efficient GTP hydrolysis, the molecular mechanisms governing these activities have remained poorly defined. In recent years, there has been an explosion of structural data… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

DNM1 encephalopathy

Neurology • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 72 references

Crystal structure of nucleotide-free dynamin

Nature • 2011
View 18 Excerpts
Highly Influenced

Dynamin: functional design of a membrane fission catalyst.

Annual review of cell and developmental biology • 2011
View 5 Excerpts
Highly Influenced

The crystal structure of dynamin

View 15 Excerpts
Highly Influenced

Arabidopsis dynamin-related proteins DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…