Building a fission machine--structural insights into dynamin assembly and activation.

  title={Building a fission machine--structural insights into dynamin assembly and activation.},
  author={Joshua S Chappie and Fred Dyda},
  journal={Journal of cell science},
  volume={126 Pt 13},
Dynamin is a large multidomain GTPase that assembles into helical arrays around the necks of deeply invaginated clathrin-coated pits and catalyzes membrane fission during the final stages of endocytosis. Although it is well established that the function of dynamin in vivo depends on its oligomerization and its capacity for efficient GTP hydrolysis, the molecular mechanisms governing these activities have remained poorly defined. In recent years, there has been an explosion of structural data… CONTINUE READING
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