Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.

@article{LargentMilnes2013BuildingAB,
  title={Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects.},
  author={Tally Marie Largent-Milnes and Stephen W Brookshire and David P. Skinner and Katherine E Hanlon and Denise Giuvelis and Tetsuya Yamamoto and Paul A. Davis and Christopher R Campos and Pooja Nair and Srinivas Deekonda and Edward J. Bilsky and Flavio Porreca and Victor J. Hruby and Todd W. Vanderah},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2013},
  volume={347 1},
  pages={7-19}
}
The most highly abused prescription drugs are opioids used for the treatment of pain. Physician-reported drug-seeking behavior has resulted in a significant health concern among doctors trying to adequately treat pain while limiting the misuse or diversion of pain medications. In addition to abuse liability, opioid use is associated with unwanted side effects that complicate pain management, including opioid-induced emesis and constipation. This has resulted in restricting long-term doses of… CONTINUE READING
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