Building Programmable Jigsaw Puzzles with RNA

@article{Chworos2004BuildingPJ,
  title={Building Programmable Jigsaw Puzzles with RNA},
  author={Arkadiusz Chworos and Isil Severcan and Alexey Y. Koyfman and Patrick Weinkam and Emin Oroudjev and Helen Greenwood Hansma and Luc Jaeger},
  journal={Science},
  year={2004},
  volume={306},
  pages={2068 - 2072}
}
One challenge in supramolecular chemistry is the design of versatile, self-assembling building blocks to attain total control of arrangement of matter at a molecular level. We have achieved reliable prediction and design of the three-dimensional structure of artificial RNA building blocks to generate molecular jigsaw puzzle units called tectosquares. They can be programmed with control over their geometry, topology, directionality, and addressability to algorithmically self-assemble into a… 

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