Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment

@article{Karunasena2010BuildingAssociatedND,
  title={Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment},
  author={Enusha Karunasena and Michael D. Larra{\~n}aga and Jan Simoni and D. Richman Douglas and David C. Straus},
  journal={Mycopathologia},
  year={2010},
  volume={170},
  pages={377-390}
}
Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell… 
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References

SHOWING 1-10 OF 63 REFERENCES
DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants Is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration
TLDR
There was an acceleration of Alzheimer's-type pathology in dogs chronically exposed to air pollutants, suggesting that Alzheimer's disease may be the sequela of air pollutant exposures and the resulting systemic inflammation.
Air Pollution and Brain Damage
TLDR
Persistent pulmonary infl ammation and deteriorating olfactory and respiratory barriers may play a role in the neuropathology observed in the brains of these highly exposed canines.
Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment.
TLDR
It is concluded that prolonged and intense exposure to toxigenic S. chartarum and other atypical fungi was associated with reported disorders of the respiratory and central nervous systems, reported Disorders of the mucous membranes and a few parameters pertaining to the cellular and humoral immune system, suggesting a possible immune competency dysfunction.
Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure.
TLDR
It is suggested that RA markedly induced FAS and proinflammatory cytokine expression prior to evoking OSN apoptosis and OE atrophy and that RA's effects were augmented by LPS.
Translocation and potential neurological effects of fine and ultrafine particles a critical update
TLDR
Morphometric analysis of the CNS indicated unequivocally that the brain is a critical target for PM Exposure and implicated oxidative stress as a predisposing factor that links PM exposure and susceptibility to neurodegeneration.
Brainstem auditory evoked response in adolescents with acoustic mycotic neuroma due to environmental exposure to toxic molds
TLDR
Overall results showed the presence of acoustic mycotic neuroma and confirmed the sensitivity and usefulness of BAER in screening acoustic mydynoma and sensorineural auditory dysfunction.
Stachybotrys, a mycotoxin-producing fungus of increasing toxicologic importance.
TLDR
Current data on the toxicology of mycotoxins produced by Stachybotrys demonstrate that this group of myotoxins is capable of producing immunosuppression and inflammatory insults to gastrointestinal and pulmonary systems.
Is damage in central nervous system due to inflammation?
The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles
TLDR
It is pointed out here that 3 different conventional pathogenic particle types, PM10, asbestos and quartz, which cause diverse pathological effects, have been reported to cause very similar oxidative stress effects in cells in culture.
Neuropathogenic actions of cytokines assessed in transgenic mice
  • I. Campbell
  • Biology
    International Journal of Developmental Neuroscience
  • 1995
...
1
2
3
4
5
...