Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment

  title={Building-Associated Neurological Damage Modeled in Human Cells: A Mechanism of Neurotoxic Effects by Exposure to Mycotoxins in the Indoor Environment},
  author={Enusha Karunasena and Michael D. Larra{\~n}aga and Jan Simoni and D. Richman Douglas and David C. Straus},
Damage to human neurological system cells resulting from exposure to mycotoxins confirms a previously controversial public health threat for occupants of water-damaged buildings. Leading scientific organizations disagree about the ability of inhaled mycotoxins in the indoor environment to cause adverse human health effects. Damage to the neurological system can result from exposure to trichothecene mycotoxins in the indoor environment. This study demonstrates that neurological system cell… 
A Review of the Mechanism of Injury and Treatment Approaches for Illness Resulting from Exposure to Water-Damaged Buildings, Mold, and Mycotoxins
  • J. Hope
  • Medicine
  • 2013
The scientific literature as it relates to commonly used treatments such as glutathione, antioxidants, antifungals, and sequestering agents such as Cholestyramine, charcoal, clay and chlorella, antioxidant, probiotics, and induced sweating are reviewed.
Mechanisms of Mycotoxin-Induced Neurotoxicity through Oxidative Stress-Associated Pathways
  • K. Doi, K. Uetsuka
  • Biology, Chemistry
    International journal of molecular sciences
  • 2011
The mechanisms of neurotoxicity induced by these mycotoxins especially from the viewpoint of oxidative stress-associated pathways are reviewed.
Effects of Mycotoxins on Neuropsychiatric Symptoms and Immune Processes.
Inhalation Exposure and Toxic Effects of Mycotoxins
Evidence for brain and systemic effects from mycotoxins is presented and the complexity of secondary metabolites produced through interaction and competition among microfungi and bacteria in damp indoor environments is discussed.
Association of toxic indoor air with multi-organ symptoms in pupils attending a moisture-damaged school in Finland.
Indoor air toxicity and dampness-related microbiota recovered from the classrooms were associated with multi-organ morbidity of the school occupants and corroborated previous reports from two adult cohorts i.e. evidence of causality.
An Exposure Model for Identifying Health Risk due to Environmental Microbial Contamination in the Healthcare Setting
It is widely accepted in various scientific communities that indoor microbiological contamination presents unacceptable conditions for the preservation of human health, and that removal and
Development of New-Onset Chronic Inflammatory Demyelinating Polyneuropathy Following Exposure to a Water-Damaged Home With High Airborne Mold Levels: A Report of Two Cases and a Review of the Literature
Clinicians who treat patients with CIDP and other peripheral neuropathies need to consider and document environmental and occupational exposures as potential triggers for neurological damage.
Literature review of current research on health effects and accepted guidelines for the management of indoor mould and water damage in the built environment
This paper reviews the many position statements, alerts, advisory notes, guidelines and white paper documents and available current scientific research on the health effects, assessment, prevention and remediation of indoor mould and water damage in the built environment.


DNA Damage in Nasal and Brain Tissues of Canines Exposed to Air Pollutants Is Associated with Evidence of Chronic Brain Inflammation and Neurodegeneration
There was an acceleration of Alzheimer's-type pathology in dogs chronically exposed to air pollutants, suggesting that Alzheimer's disease may be the sequela of air pollutant exposures and the resulting systemic inflammation.
Air Pollution and Brain Damage
Persistent pulmonary infl ammation and deteriorating olfactory and respiratory barriers may play a role in the neuropathology observed in the brains of these highly exposed canines.
Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment.
It is concluded that prolonged and intense exposure to toxigenic S. chartarum and other atypical fungi was associated with reported disorders of the respiratory and central nervous systems, reported Disorders of the mucous membranes and a few parameters pertaining to the cellular and humoral immune system, suggesting a possible immune competency dysfunction.
Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure.
It is suggested that RA markedly induced FAS and proinflammatory cytokine expression prior to evoking OSN apoptosis and OE atrophy and that RA's effects were augmented by LPS.
Translocation and potential neurological effects of fine and ultrafine particles a critical update
Morphometric analysis of the CNS indicated unequivocally that the brain is a critical target for PM Exposure and implicated oxidative stress as a predisposing factor that links PM exposure and susceptibility to neurodegeneration.
Brainstem auditory evoked response in adolescents with acoustic mycotic neuroma due to environmental exposure to toxic molds
Overall results showed the presence of acoustic mycotic neuroma and confirmed the sensitivity and usefulness of BAER in screening acoustic mydynoma and sensorineural auditory dysfunction.
Stachybotrys, a mycotoxin-producing fungus of increasing toxicologic importance.
Current data on the toxicology of mycotoxins produced by Stachybotrys demonstrate that this group of myotoxins is capable of producing immunosuppression and inflammatory insults to gastrointestinal and pulmonary systems.
Is damage in central nervous system due to inflammation?
The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles
It is pointed out here that 3 different conventional pathogenic particle types, PM10, asbestos and quartz, which cause diverse pathological effects, have been reported to cause very similar oxidative stress effects in cells in culture.
Neuropathogenic actions of cytokines assessed in transgenic mice
  • I. Campbell
  • Biology
    International Journal of Developmental Neuroscience
  • 1995