BuildSummary: using a group-based approach to improve the sensitivity of peptide/protein identification in shotgun proteomics.

The target-decoy database search strategy is widely accepted as a standard method for estimating the false discovery rate (FDR) of peptide identification, based on which peptide-spectrum matches (PSMs) from the target database are filtered. To improve the sensitivity of protein identification given a fixed accuracy (frequently defined by a protein FDR… CONTINUE READING