BuildBeta--a system for automatically constructing beta sheets.

  title={BuildBeta--a system for automatically constructing beta sheets.},
  author={Nelson Max and Chengcheng Hu and Oliver Kreylos and Silvia N. Crivelli},
  volume={78 3},
We describe a method that can thoroughly sample a protein conformational space given the protein primary sequence of amino acids and secondary structure predictions. Specifically, we target proteins with beta-sheets because they are particularly challenging for ab initio protein structure prediction because of the complexity of sampling long-range strand pairings. Using some basic packing principles, inverse kinematics (IK), and beta-pairing scores, this method creates all possible beta-sheet… CONTINUE READING


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