Bufotenine reconsidered

@article{Mcleod1985BufotenineR,
  title={Bufotenine reconsidered},
  author={W R Mcleod and Balvant R. Sitaram},
  journal={Acta Psychiatrica Scandinavica},
  year={1985},
  volume={72}
}
ABSTRACT– Bufotenine given intravenously to a medically trained volunteer subject correlated with the appearance of profound perceptual and emotional changes which were of short duration. The compound rapidly disappeared from the blood and metabolites quickly appeared in the urine of the subject. 

Bufotenine: Toward an Understanding of Possible Psychoactive Mechanisms

Support is shown for the rationale that the reported lack of the drug's classic hallucinogenic response in human experiments is due to poor ability to cross the blood brain barrier (BBB), not lack of activation of the appropriate brain receptors.

Pharmañopo—Psychonautics: Human Intranasal, Sublingual, Intrarectal, Pulmonary and Oral Pharmacology of Bufotenine

  • J. Ott
  • Biology
    Journal of psychoactive drugs
  • 2001
Psychoptic activity of bufotenine has been established and the 1967 Holmstedt–Lindgren hypothesis of the paricá effect—intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAOI) β-carbolines from stems of Banisteriopsis caapi admixed with the snuffs—has been confirmed by 25 psychonautic bioassays.

Pharmaiiopo-Psychonautics : Huntan Intranasal , Sublingual , lntrarectal , Pulntonary and Oral Pharmacology of Bufoteninet

Psychoptic (visionary) activity of bufotenine has been established and the Holmstedt-Lindgren hypothesis of the paricti effect-intranasal potentiation of tryptamines by concomitant administration of monoamine-oxidase-inhibiting (MAO!) P-carbolines from stems of Banisteriopsis caapi admixed with the snuffs-has been confirmed by 25 psychonautic bioassays.

Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions.

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) belongs to a group of naturally-occurring psychoactive indolealkylamine drugs. It acts as a nonselective serotonin (5-HT) agonist and causes many

Taking Different Roads: l-Tryptophan as the Origin of Psilocybe Natural Products.

The focus is laid on l-tryptophan and the various Psilocybe natural products and their metabolic routes are highlighted, and pharmacological, medicinal, ecological, biochemical, and evolutionary aspects are included.

Metabolomic Strategies in Biomarker Research–New Approach for Indirect Identification of Drug Consumption and Sample Manipulation in Clinical and Forensic Toxicology?

More studies, including more sensitive targeted analyses, multi-variant statistical models or deep-learning approaches are needed to fully explore the potential of omics science in DOA testing.

References

SHOWING 1-10 OF 13 REFERENCES

A Longitudinal Study of Urinary Excretion of N,N,-Dimethyltryptamine in Psychotic Patients

It is suggested that the extracerebral production of DMT (as measured by its urinary excretion) does not provoke the experience of hallucinations in psychotic patients.

The psychedelic model of schizophrenia: the case of N,N-dimethyltryptamine.

The authors review the research on DMT as a possible "schizotoxin" and conclude that more data are necessary before the validity of this theory can be determined.

Indole(ethy1)amine N-methyl

    The urinary excretion of dimethyltryptamine is raised in liver disease

    • Am J Psychiatry
    • 1979