Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.

@article{Yano2006BuforminST,
  title={Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.},
  author={A. Yano and Masafumi Kubota and K. Iguchi and S. Usui and K. Hirano},
  journal={Biological \& pharmaceutical bulletin},
  year={2006},
  volume={29 5},
  pages={
          1006-9
        }
}
The biguanides metformin and buformin, which are clinically used for diabetes mellitus, are known to improve resistance to insulin in patients. Biguanides were reported to cause lactic acidosis as a side effect. Since the mechanism of the side effect still remains obscure, we have examined genes whose expression changes by treating HepG2 cells with buformin in order to elucidate the mechanisms of the side effect. A subtraction cDNA library was constructed by the method of suppressive… Expand
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