Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.

@article{Yano2006BuforminST,
  title={Buformin suppresses the expression of glyceraldehyde 3-phosphate dehydrogenase.},
  author={A. Yano and Masafumi Kubota and K. Iguchi and S. Usui and K. Hirano},
  journal={Biological \& pharmaceutical bulletin},
  year={2006},
  volume={29 5},
  pages={
          1006-9
        }
}
The biguanides metformin and buformin, which are clinically used for diabetes mellitus, are known to improve resistance to insulin in patients. Biguanides were reported to cause lactic acidosis as a side effect. Since the mechanism of the side effect still remains obscure, we have examined genes whose expression changes by treating HepG2 cells with buformin in order to elucidate the mechanisms of the side effect. A subtraction cDNA library was constructed by the method of suppressive… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
The mechanisms by which mild respiratory chain inhibitors inhibit hepatic gluconeogenesis.
TLDR
The effects of phenylethylbiguanide (phenformin) on the rate of gluconeogenesis and metabolite profiles in the perfused liver are similar to those caused by DCMU, supporting a mitochondrial locus of action for this hypoglycaemic agent. Expand
The mechanism of action of phenformin in starved rats.
The ability of phenformin to lower the blood glucose concentration after an intraperitoneal glucose load, with a concomitant increase in blood lactate concentration, indicated that the drug wasExpand
Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression.
TLDR
It is suggested that benfluorex mainly via S 422-1 reduces gluconeogenesis by affecting gene expression and metabolic status of hepatocytes. Expand
The effect of alkylguanidines on mitochondrial metabolism.
  • J. Chappell
  • Biology, Medicine
  • The Journal of biological chemistry
  • 1963
TLDR
Findings indicate that the alkylguanidines combine with an energy-rich intermediate involved in the phosphorylation process, and oligomycin inhibited oxidation equally well in both the active and resting phases of respiration. Expand
Effects of guanidine derivatives on mitochondrial function. 3. The mechanism of phenethylbiguanide accumulation and its relationship to in vitro respiratory inhibition.
  • F. Davidoff
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 1971
TLDR
The data appear to be more consistent with a nonionic diffusion mechanism of biguanide uptake, with final distribution determined by the transmembrane pH gradient, than with distribution according to a trans Membrane electrical potential. Expand
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function.
TLDR
The data strongly support the view that MET may recognise some specific membranous sites, likely belonging to effector systems, before penetrating the cell in a bound state via an obscure endocytotic event which still has to be identified. Expand
Evidence that the flux control coefficient of the respiratory chain is high during gluconeogenesis from lactate in hepatocytes from starved rats. Implications for the hormonal control of gluconeogenesis and action of hypoglycaemic agents.
TLDR
It is concluded that the hormonal increase in mitochondrial matrix volume stimulates fatty acid oxidation and respiratory-chain activity, allowing stimulation of pyruvate carboxylation and thus gluconeogenesis to occur without major changes in [ATP]/[ADP] or [NADH]/,[NAD+] ratios. Expand
Mode of action of hypoglycemic agents. V. Studies with phenethylbiguanide in isolated perfused rat liver.
TLDR
The results presented and discussed are interpreted to indicate that phenethylbiguanide influences hepatic gluconeogenesis by an indirect mechanism. Expand
Interaction of biguanides with mitochondrial and synthetic membranes.
TLDR
It is concluded that a similar mechanism of action applies to synthetic and natural membranes as well, suggesting that screening of functional negative sites interferes with the translocation of cations linked to electron transport and the primary reactions in conservation of respiratory energy. Expand
Effect of metformin on fatty acid and glucose metabolism in freshly isolated hepatocytes and on specific gene expression in cultured hepatocytes.
TLDR
It was shown that the main effect of metformin on hepatic gluconeogenesis was located upstream of the formation of dihydroxyacetone phosphate, and this work suggests that met formin could reduce hepatic glucose production through short-term (metabolic) and long- term (genic) effects. Expand
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