Buffering the pH of the culture medium does not extend yeast replicative lifespan

  title={Buffering the pH of the culture medium does not extend yeast replicative lifespan},
  author={Brian M. Wasko and Daniel T Carr and Herman Tung and Ha Doan and Nathan Schurman and Jillian R Neault and Joey Feng and Janet J Lee and Ben Zipkin and J Garret Mouser and Edward Oudanonh and Tina Nguyen and Torin F Stetina and Anna Shemorry and Mekedes Lemma and Matt Kaeberlein and Cory D Dunn and Karim Mekhail},
During chronological aging of budding yeast cells, the culture medium can become acidified, and this acidification limits cell survival.  As a consequence, buffering the culture medium to pH 6 significantly extends chronological life span under standard conditions in synthetic medium.  In this study, we assessed whether a similar process occurs during replicative aging of yeast cells.  We find no evidence that buffering the pH of the culture medium to pH levels either higher or lower than the… CONTINUE READING
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