Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster

@inproceedings{Lundberg2012BufferingAP,
  title={Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster},
  author={Lina E. Lundberg and Margarida L. A. Figueiredo and Per Stenberg and Jan Larsson},
  booktitle={Nucleic acids research},
  year={2012}
}
Variation in the number of individual chromosomes (chromosomal aneuploidy) or chromosome segments (segmental aneuploidy) is associated with developmental abnormalities and reduced fitness in all species examined; it is the leading cause of miscarriages and mental retardation and a hallmark of cancer. However, despite their documented importance in disease, the effects of aneuploidies on the transcriptome remain largely unknown. We have examined the expression effects of seven heterozygous… CONTINUE READING
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