Bufalin loaded biotinylated chitosan nanoparticles: an efficient drug delivery system for targeted chemotherapy against breast carcinoma.

@article{Tian2014BufalinLB,
  title={Bufalin loaded biotinylated chitosan nanoparticles: an efficient drug delivery system for targeted chemotherapy against breast carcinoma.},
  author={Xin Shirley Tian and Hongzhuan Yin and Shichen Zhang and Ying Luo and Kai Xu and Ping Ma and C. Kloeppels K. Sui and Fandong Meng and Yunpeng Liu and Youhong Jiang and Jun Fang},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={87 3},
  pages={
          445-53
        }
}
Bufalin is a traditional oriental medicine which is known to induce apoptosis in many tumor cells, and it is thus considered as a new anticancer therapeutic. By now, most of the studies of bufalin are in vitro, however in vivo evaluations of its therapeutic efficacy are less and are in great demand for its development toward anticancer drug. One of the problems probably hampering the development of bufalin is the lack of tumor selectivity, which may reduce the therapeutic effect as well as… CONTINUE READING
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