Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.

@article{Wang2014BufalinIA,
  title={Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1.},
  author={Ying N. Wang and David M. Lonard and Yang Yu and D Chow and Timothy G. Palzkill and Jin Wang and Ruogu Qi and Alexander J Matzuk and Xianzhou Song and Franck Madoux and Peter S. Hodder and Peter Chase and Patrick R. Griffin and Suoling Zhou and Lan Liao and Jianming M Xu and Bert W. O'malley},
  journal={Cancer research},
  year={2014},
  volume={74 5},
  pages={1506-1517}
}
Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery. Coactivators have been implicated in cancer cell proliferation, invasion, and metastasis, including the p160 steroid receptor coactivator (SRC) family composed of SRC-1 (NCOA1), SRC-2 (TIF2/GRIP1/NCOA2… CONTINUE READING