Budesonide prevents cytokine-induced decrease of the relaxant responses to formoterol and terbutaline, but not to salmeterol, in mouse trachea.

@article{Adner2010BudesonidePC,
  title={Budesonide prevents cytokine-induced decrease of the relaxant responses to formoterol and terbutaline, but not to salmeterol, in mouse trachea.},
  author={Mikael Adner and B. Larsson and Jesper S{\"a}fholm and Ian Naya and Anna Miller-Larsson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={333 1},
  pages={273-80}
}
During asthma exacerbations, increased airway inflammation may impair the effects of beta(2)-adrenoceptor (beta(2)AR) agonists. It is unclear whether this impairment is prevented by inhaled glucocorticoids (GCs). We have investigated the relaxation of carbachol-contracted mouse tracheal segments to the beta(2)AR agonists formoterol, terbutaline, and salmeterol. The segments were pre-exposed for 4 days to the proinflammatory cytokines tumor necrosis factor alpha (100 ng/ml) and interleukin-1beta… CONTINUE READING

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