Budesonide added to modified porcine surfactant Curosurf may additionally improve the lung functions in meconium aspiration syndrome.

@article{Mikolka2013BudesonideAT,
  title={Budesonide added to modified porcine surfactant Curosurf may additionally improve the lung functions in meconium aspiration syndrome.},
  author={Pavol Mikolka and Daniela Mokra and Jana Kopincov{\'a} and L Tom{\vc}{\'i}kov{\'a}-Miku{\vs}iakov{\'a} and Andrea Calkovska},
  journal={Physiological research},
  year={2013},
  volume={62 Suppl 1},
  pages={S191-200}
}
Severe meconium aspiration syndrome (MAS) in newborns is often treated by exogenous surfactant. Because its efficacy is reduced by meconium-induced inflammation, glucocorticoid budesonide was added into surfactant preparation Curosurf to enhance efficacy of the surfactant therapy in experimental model of MAS. Oxygen-ventilated rabbits were intratracheally given meconium (25 mg/ml, 4 ml/kg) to induce respiratory failure. Thirty minutes later, animals were treated by intratracheal budesonide (0… CONTINUE READING