Budesonide/formoterol effects on metalloproteolytic balance in TGFbeta-activated human lung fibroblasts.

  title={Budesonide/formoterol effects on metalloproteolytic balance in TGFbeta-activated human lung fibroblasts.},
  author={Lizbet Todorova and Eylem G{\"u}rcan and Gunilla Westergren-Thorsson and Anna Miller-Larsson},
  journal={Respiratory medicine},
  volume={103 11},
In the airways of asthmatic patients, activated fibroblasts account for an excessive matrix production including proteoglycans (PGs). Transforming growth factor-beta (TGFbeta), metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play key roles in matrix turnover. It is unclear whether asthma therapy with combination of inhaled glucocorticoids and long-acting beta(2)-agonists affects metalloproteolytic equilibrium and by that counteracts airway fibrosis. The effects of the… CONTINUE READING


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