Budding yeast PAK kinases regulate mitotic exit by two different mechanisms

  title={Budding yeast PAK kinases regulate mitotic exit by two different mechanisms},
  author={Elena Chiroli and Roberta Fraschini and Alessia Beretta and Mariagrazia Tonelli and G. Lucchini and Simonetta Piatti},
  journal={The Journal of Cell Biology},
  pages={857 - 874}
We report the characterization of the dominant-negative CLA4t allele of the budding yeast CLA4 gene, encoding a member of the p21-activated kinase (PAK) family of protein kinases, which, together with its homologue STE20, plays an essential role in promoting budding and cytokinesis. Overproduction of the Cla4t protein likely inhibits both endogenous Cla4 and Ste20 and causes a delay in the onset of anaphase that correlates with inactivation of Cdc20/anaphase-promoting complex (APC)-dependent… CONTINUE READING


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