Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression.

@article{Hrkk2006BuddingIM,
  title={Budding invasive margin and prognosis in colorectal cancer--no direct association with beta-catenin expression.},
  author={Tuomo T H{\"o}rkk{\"o} and Kai Hans Klintrup and Johanna M M{\"a}kinen and Juha B N{\"a}p{\"a}nkangas and Hannu J Tuominen and Jyrki M{\"a}kel{\"a} and Tuomo Juhani Karttunen and Markus J. M{\"a}kinen},
  journal={European journal of cancer},
  year={2006},
  volume={42 7},
  pages={964-71}
}
Cancer cell budding at the invasive margin has been associated with poor prognosis in rectal cancer. beta-Catenin is an adhesion protein involved in the nuclear Wnt/beta-catenin pathway, and mesenchymal transition of colorectal cancer cells. Hence, we investigated the relationship between cancer cell budding at the invasive margin, beta-catenin expression, and 5-year-survival in colorectal cancer. Four hundred and sixty six colorectal cancer specimens were analysed for budding margin, and 108… CONTINUE READING

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