Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.

@article{Pan2008BudSN,
  title={Bud specific N-sulfation of heparan sulfate regulates Shp2-dependent FGF signaling during lacrimal gland induction.},
  author={Yi Pan and Christian Carbe and Andrea Powers and Eric Erquan Zhang and Jeffrey D Esko and Kay Grobe and Gen-sheng Feng and Xin Zhang},
  journal={Development},
  year={2008},
  volume={135 2},
  pages={301-10}
}
Preferential outgrowth of the bud cells forms the basis of branching morphogenesis. Here, we show that lacrimal gland development requires specific modification of heparan sulfates by Ndst genes at the tip of the lacrimal gland bud. Systemic and conditional knockout experiments demonstrate the tissue specific requirement of Ndst1 and Ndst2 in the lacrimal gland epithelial, but not mesenchymal, cells, and the functional importance of Ndst1 in Fgf10-Fgfr2b, but not of Fgf1-Fgfr2b, complex… CONTINUE READING