Buckling of lipidic ultrasound contrast agents under quasi-static load

@article{Chabouh2022BucklingOL,
  title={Buckling of lipidic ultrasound contrast agents under quasi-static load},
  author={Georges Chabouh and Benjamin van Elburg and Michel Versluis and Tim Segers and Catherine Quilliet and G. Coupier},
  journal={Philosophical Transactions of the Royal Society A},
  year={2022},
  volume={381}
}
Collapse of lipidic ultrasound contrast agents under high-frequency compressive load has been historically interpreted by the vanishing of surface tension. By contrast, buckling of elastic shells is known to occur when costly compressible stress is released through bending. Through quasi-static compression experiments on lipidic shells, we analyse the buckling events in the framework of classical elastic buckling theory and deduce the mechanical characteristics of these shells. They are then… 

Figures and Tables from this paper

Foreword to the special issue on new developments in structural stability

implementing machine

References

SHOWING 1-10 OF 87 REFERENCES

Buckling resistance of solid shell bubbles under ultrasound.

Numerical simulations that explicitly incorporate a shell bending modulus give the critical buckling pressure and post-buckling shape, and show the appearance of a finite number of wrinkles.

High-precision acoustic measurements of the nonlinear dilatational elasticity of phospholipid coated monodisperse microbubbles.

Detailed features of the nonlinear dilatational shell behavior of micron-sized lipid-coated bubbles are revealed by tuning the surface dilatation of well-controlled monodisperse bubble suspensions through the ambient pressure.

Nonlinear shell behavior of phospholipid-coated microbubbles.

A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture

We present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble. Three parameters describe the

Correlation of rupture dynamics to the nonlinear backscatter response from polymer-shelled ultrasound contrast agents

Results indicate the mechanism of gas expulsion from these UCAs might be a relevant factor in determining the level of subharmonic response in response to high-frequency ultrasound.

Delayed buckling of spherical shells due to viscoelastic knockdown of the critical load

We performed dynamic pressure buckling experiments on defect-seeded spherical shells made of a common silicone elastomer. Unlike in quasi-static experiments, shells buckled at ostensibly subcritical

Dynamic acousto-elastic testing applied to a highly dispersive medium and evidence of shell buckling of lipid-coated gas microbubbles.

A frequency-domain analysis shows that the acousto-elastic effect (first order pressure derivative of ultrasound phase velocity) depends on the ultrasound frequency, and supports the occurrence of shell buckling of lipid-coated microbubbles induced by the 16 kHz pressure wave.

Microbubble spectroscopy of ultrasound contrast agents.

The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping.

Rupture threshold characterization of polymer-shelled ultrasound contrast agents subjected to static overpressure.

The fragility of two polymer-shelled UCAs manufactured by Point Biomedical or Philips Research was investigated by characterizing their response to static overpressure, with results that may provide means to optimize polymeric UCAs for drug delivery and elucidate associated mechanisms.

"Compression-only" behavior: a second-order nonlinear response of ultrasound contrast agent microbubbles.

A theoretical understanding of the source of the compression-only behavior of oscillating phospholipid-coated ultrasound contrast agent microbubbles is provided through a weakly nonlinear analysis of the shell buckling model proposed by Marmottant et al.
...