Buchwald-Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst.

Abstract

The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr((NMe2)2) incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.

DOI: 10.1021/acs.joc.5b01272

Cite this paper

@article{Zhang2015BuchwaldHartwigAO, title={Buchwald-Hartwig Amination of (Hetero)Aryl Tosylates Using a Well-Defined N-Heterocyclic Carbene/Palladium(II) Precatalyst.}, author={Yin Zhang and Guy Lavigne and Vincent C{\'e}sar}, journal={The Journal of organic chemistry}, year={2015}, volume={80 15}, pages={7666-73} }