Bubbles, gating, and anesthetics in ion channels.

@article{Roth2008BubblesGA,
  title={Bubbles, gating, and anesthetics in ion channels.},
  author={R. Roth and D. Gillespie and W. Nonner and Robert E Eisenberg},
  journal={Biophysical journal},
  year={2008},
  volume={94 11},
  pages={
          4282-98
        }
}
We suggest that bubbles are the bistable hydrophobic gates responsible for the on-off transitions of single channel currents. In this view, many types of channels gate by the same physical mechanism-dewetting by capillary evaporation-but different types of channels use different sensors to modulate hydrophobic properties of the channel wall and thereby trigger and control bubbles and gating. Spontaneous emptying of channels has been seen in many simulations. Because of the physics involved… Expand
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  • 4
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  • 249
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  • Highly Influenced
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  • 74
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  • 4
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  • 11
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References

SHOWING 1-10 OF 233 REFERENCES
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.
  • 246
  • Highly Influential
Water in ion channels and pores--simulation studies.
  • 20
The voltage sensor and the gate in ion channels.
  • 34
Effect of high hydrostatic pressure on the bacterial mechanosensitive channel MscS
  • 23
Proteins, channels and crowded ions.
  • 71
  • PDF
Gated, ion-selective channels observed with patch pipettes in the absence of membranes: novel properties of a gigaseal.
  • 51
Molecular restraints in the permeation pathway of ion channels.
  • 29
  • PDF
The ionic channels in excitable membranes.
  • R. Keynes
  • Chemistry, Medicine
  • Ciba Foundation symposium
  • 1975
  • 2,468
  • Highly Influential
...
1
2
3
4
5
...