Bubble-free oxygenation of a bi-enzymatic system: effect on biocatalyst stability.

@article{Hecke2009BubblefreeOO,
  title={Bubble-free oxygenation of a bi-enzymatic system: effect on biocatalyst stability.},
  author={Wouter Van Hecke and Roland Ludwig and Jo lle Dewulf and Markus Auly and Tom Messiaen and Dietmar Haltrich and Herman R Van Langenhove},
  journal={Biotechnology and bioengineering},
  year={2009},
  volume={102 1},
  pages={122-31}
}
The effect of bubble-free oxygenation on the stability of a bi-enzymatic system with redox mediator regeneration for the conversion of lactose to lactobionic acid was investigated in a miniaturized reactor with bubbleless oxygenation. Earlier investigations of this biocatalytic oxidation have shown that the dispersive addition of oxygen can cause significant enzyme inactivation. In the process studied, the enzyme cellobiose dehydrogenase (CDH) oxidizes lactose at the C-1 position of the… CONTINUE READING

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