BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment

@article{Zhang2007BubR1AA,
  title={BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment},
  author={Jiayin Zhang and Sana Ahmad and Yinghui Mao},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={178},
  pages={773 - 784}
}
The accurate segregation of chromosomes in mitosis requires the stable attachment of microtubules to kinetochores. The details of this complex and dynamic process are poorly understood. In this study, we report the interaction of a kinetochore-associated mitotic checkpoint kinase, BubR1, with two microtubule plus end-associated proteins, adenomatous polyposis coli (APC) and EB1, providing a potential link in stable kinetochore microtubule attachment. Using immunodepletion from and antibody… CONTINUE READING

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