Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

  title={Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling},
  author={Ivana Primorac and John R. Weir and Elena Chiroli and Fridolin Gross and Ingrid Hoffmann and Suzan van Gerwen and Andrea Ciliberto and Andrea Musacchio},
Regulation of macromolecular interactions by phosphorylation is crucial in signaling networks. In the spindle assembly checkpoint (SAC), which enables errorless chromosome segregation, phosphorylation promotes recruitment of SAC proteins to tensionless kinetochores. The SAC kinase Mps1 phosphorylates multiple Met-Glu-Leu-Thr (MELT) motifs on the kinetochore subunit Spc105/Knl1. The phosphorylated MELT motifs (MELT(P)) then promote recruitment of downstream signaling components. How MELT(P… CONTINUE READING
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