Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.

@article{Hu2002Bub2IA,
  title={Bub2 is a cell cycle regulated phospho-protein controlled by multiple checkpoints.},
  author={Fenghua Hu and Stephen J Elledge},
  journal={Cell cycle},
  year={2002},
  volume={1 5},
  pages={351-5}
}
During mitotic exit, a small GTPase Tem1 needs to be activated. During most of the cell cycle, Tem1 activity is antagonized by a GTPase activating complex (GAP) composed of Bub2 and Bfa1. Bfa1 protein has cell cycle regulated phosphorylation depending upon the Polo-like kinase Cdc5. This phosphorylation dissociates Bfa1 from Tem1 and thus relieves the inhibition of Tem1 by the GAP complex. Bub2 and Bfa1 are also required to prevent mitotic exit when there is DNA damage, spindle damage or… CONTINUE READING

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