Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation


High expression of the protein kinase Bub1 has been observed in a variety of human tumors and often correlates with poor clinical prognosis, but its molecular and cellular consequences and role in tumorigenesis are unknown. Here, we demonstrate that overexpression of Bub1 in mice leads to near-diploid aneuploidies and tumor formation. We found that… (More)
DOI: 10.1083/jcb.201012035


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