Bub1 is activated by the protein kinase p90Rsk during Xenopus oocyte maturation

BACKGROUND The kinetochore attachment (spindle assembly) checkpoint arrests cells in metaphase to prevent exit from mitosis until all the chromosomes are aligned properly at the metaphase plate. The checkpoint operates by preventing activation of the anaphase-promoting complex (APC), which triggers anaphase by degrading mitotic cyclins and other proteins… CONTINUE READING