Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.

@article{Xiao2010Bub1AC,
  title={Bub1 and CENP-F can contribute to Kaposi's sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores.},
  author={Bingyi Xiao and Subhash C Verma and Qiliang Cai and Rajeev Kaul and Jie Lu and Abhik Saha and Erle S Robertson},
  journal={Journal of virology},
  year={2010},
  volume={84 19},
  pages={9718-32}
}
The latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) is critical for segregation of viral episomes to progeny nuclei and allows for maintenance of the viral genome in newly divided daughter cells. LANA binds to KSHV terminal repeat (TR) DNA and simultaneously associates with chromatin-bound cellular proteins. This process tethers the viral episomes to host chromosomes. However, the mechanism of tethering is complex and involves multiple protein… CONTINUE READING