Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint.

@article{Elowe2011Bub1AB,
  title={Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint.},
  author={S Elowe},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 15},
  pages={3085-93}
}
The spindle checkpoint ensures genome fidelity by temporarily halting chromosome segregation and the ensuing mitotic exit until the last kinetochore is productively attached to the mitotic spindle. At the interface between proper chromosome attachment and the metaphase-to-anaphase transition are the mammalian spindle checkpoint kinases. Compelling evidence indicates that the checkpoint kinases Bub1 and BubR1 have the added task of regulating kinetochore-microtubule attachments. However, the… CONTINUE READING

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