Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast

@inproceedings{Kanneganti2011Btn3IA,
  title={Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast},
  author={Vydehi Kanneganti and Rachel Kama and Jeffrey E Gerst},
  booktitle={Molecular biology of the cell},
  year={2011}
}
Yeast Btn2 facilitates the retrieval of specific proteins from late endosomes (LEs) to the Golgi, a process that may be adversely affected in Batten disease patients. We isolated the putative yeast orthologue of a human complex I deficiency gene, designated here as BTN3, as encoding a Btn2-interacting protein and negative regulator. First, yeast overexpressing BTN3 phenocopy the deletion of BTN2 and mislocalize certain trans-Golgi proteins, like Kex2 and Yif1, to the LE and vacuole… CONTINUE READING

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