Btn3 is a negative regulator of Btn2-mediated endosomal protein trafficking and prion curing in yeast

Abstract

Yeast Btn2 facilitates the retrieval of specific proteins from late endosomes (LEs) to the Golgi, a process that may be adversely affected in Batten disease patients. We isolated the putative yeast orthologue of a human complex I deficiency gene, designated here as BTN3, as encoding a Btn2-interacting protein and negative regulator. First, yeast… (More)
DOI: 10.1091/mbc.E10-11-0878

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