Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants.

@article{Hartkamp2015BtkIS,
  title={Btk inhibition suppresses agonist-induced human macrophage activation and inflammatory gene expression in RA synovial tissue explants.},
  author={Linda M. Hartkamp and Jay S. Fine and Inge E. van Es and M W Tang and Michael Smith and John N Woods and Satwant K. Narula and Julie Demartino and Paul Peter Tak and Kris A. Reedquist},
  journal={Annals of the rheumatic diseases},
  year={2015},
  volume={74 8},
  pages={
          1603-11
        }
}
OBJECTIVES Bruton's tyrosine kinase (Btk) is required for B lymphocyte and myeloid cell contributions to pathology in murine models of arthritis. Here, we examined the potential contributions of synovial Btk expression and activation to inflammation in rheumatoid arthritis (RA). MATERIALS AND METHODS Btk was detected by immunohistochemistry and digital image analysis in synovial tissue from biologically naive RA (n=16) and psoriatic arthritis (PsA) (n=12) patients. Cell populations expressing… CONTINUE READING
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