Btk-dependent regulation of phosphoinositide synthesis.

  title={Btk-dependent regulation of phosphoinositide synthesis.},
  author={C. Carpenter},
  journal={Biochemical Society transactions},
  volume={32 Pt 2},
  • C. Carpenter
  • Published 2004
  • Biology, Medicine
  • Biochemical Society transactions
  • Activation of the BCR (B cell antigen receptor) stimulates the production of both PtdIns(3,4,5) P3 and Ins(1,4,5) P3. PtdIns(3,4,5) P3 and Ins(1,4,5) P3 are generated from a common substrate, PtdIns(4,5) P2. In some systems, continuous PtdIns(4,5) P2 synthesis is necessary for maximal Ins(1,4,5) P3 production, but whether this is true for the BCR, and whether PtdIns(4,5) P2 synthesis is regulated following BCR activation, are not known. We found that Btk (Bruton's tyrosine kinase), a member of… CONTINUE READING
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