• DOI:10.1042/BST0320326
Corpus ID: 41318916

Btk-dependent regulation of phosphoinositide synthesis.

@article{Carpenter2004BtkdependentRO,
  title={Btk-dependent regulation of phosphoinositide synthesis.},
  author={C. Carpenter},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt 2},
  pages={
          326-9
        }
}

C. Carpenter

Published 2004

Biology, Medicine

Biochemical Society transactions

Activation of the BCR (B cell antigen receptor) stimulates the production of both PtdIns(3,4,5) P3 and Ins(1,4,5) P3. PtdIns(3,4,5) P3 and Ins(1,4,5) P3 are generated from a common substrate, PtdIns(4,5) P2. In some systems, continuous PtdIns(4,5) P2 synthesis is necessary for maximal Ins(1,4,5) P3 production, but whether this is true for the BCR, and whether PtdIns(4,5) P2 synthesis is regulated following BCR activation, are not known. We found that Btk (Bruton's tyrosine kinase), a member of… CONTINUE READING

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