Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA

@inproceedings{Masumura2016Btg2IA,
  title={Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA},
  author={Yuki Masumura and Shuichiro Higo and Yoshihiro Asano and Hisakazu Katō and Yi Xia Yan and Saki Ishino and Osamu Tsukamoto and Hidetaka Kioka and Takaharu Hayashi and Yasunori Shintani and Satoru Yamazaki and Tomoyoshi Minamino and Masafumi Kitakaze and Issei Komuro and Seiji Takashima and Yasushi Sakata},
  booktitle={Scientific reports},
  year={2016}
}
Under hypertrophic stimulation, cardiomyocytes enter a hypermetabolic state and accelerate biomass accumulation. Although the molecular pathways that regulate protein levels are well-studied, the functional implications of RNA accumulation and its regulatory mechanisms in cardiomyocytes remain elusive. Here, we have elucidated the quantitative kinetics of RNA in cardiomyocytes through single cell imaging and c-Myc (Myc)-mediated hypermetabolic analytical model using cultured cardiomyocytes… CONTINUE READING
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