Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model

@article{Mohammad2001Bryostatin1I,
  title={Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model},
  author={Ramzi M. Mohammad and N. Volkan Adsay and Philip A Philip and George R. Pettit and Vainutis K. Vaitkevicius and Fazlul H. Sarkar},
  journal={Anti-Cancer Drugs},
  year={2001},
  volume={12},
  pages={735-740}
}
Pancreatic cancer has the worst prognosis of all cancers with a dismal 5-year survival rate. Hence, there is a tremendous need for development of new and effective therapy for this tumor. In an earlier study we reported a potent antitumor activity of Auristatin PE (AuriPE) against pancreatic tumor. In addition, we have also reported that bryostatin 1 (bryo1) induces differentiation of leukemia cells, but the effect of bryo1 has not been investigated in pancreatic tumors. This is the first… Expand
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