Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.

@article{Kino2009BrxMT,
  title={Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.},
  author={Tomoshige Kino and Hiroaki Takatori and Irini Manoli and Yonghong Wang and Anatoly Tiulpakov and Marc R. Blackman and Yan A. Su and George P. Chrousos and Alan H. Decherney and James H Segars},
  journal={Science signaling},
  year={2009},
  volume={2 57},
  pages={ra5}
}
Extracellular hyperosmolarity, or osmotic stress, generally caused by differences in salt and macromolecule concentrations across the plasma membrane, occurs in lymphoid organs and at inflammatory sites. The response of immune cells to osmotic stress is regulated by nuclear factor of activated T cells 5 (NFAT5), a transcription factor that induces the expression of hyperosmolarity-responsive genes and stimulates cytokine production. We report that the guanine nucleotide exchange factor (GEF… CONTINUE READING