Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.

@article{Kawakami1997BrutonsTK,
  title={Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity.},
  author={Yuko Kawakami and Toru Miura and Reid Bissonnette and Daisuke Hata and Wasif Noor Khan and Toshio Kitamura and Mari Maeda-Yamamoto and Stephen E. Hartman and Libo Yao and Frederick W Alt and Toshiaki Wako Kawakami},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 8},
  pages={
          3938-42
        }
}
Mast cells derived from Bruton's tyrosine kinase (Btk)-defective xid or btk null mice showed greater expansion in culture containing interleukin-3 (IL-3) than those from wild-type (wt) mice. Although the proliferative response to IL-3 was not significantly different between the wt and xid mast cells, xid and btk null mast cells died by apoptosis more slowly than their wt counterparts upon IL-3 deprivation. Consistent with these findings, the apoptosis-linked c-Jun N-terminal kinase/stress… CONTINUE READING
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