Brutonâs Tyrosine Kinase (Btk) Inhibitor Tirabrutinib Prevents the Development of Murine Lupus

@inproceedings{Ariza2019BrutonsTK,
  title={Bruton{\^a}s Tyrosine Kinase (Btk) Inhibitor Tirabrutinib Prevents the Development of Murine Lupus},
  author={Yuko Ariza and Masayuki Murata and Yoshiko Ueda and Toshio Yoshizawa},
  year={2019}
}
Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease associated with the over production of high affinity autoantibodies. Overactivity of B-cell responsiveness to immune stimulation and direct activation of circulating FcR bearing cells are sufficient to initiate inflammatory responses, which may be an essential feature of SLE pathogenesis. Here, we examined the potential efficacy of tirabrutinib using NZB/WF1 and MRL/lpr mice in the model of spontaneous SLE… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 26 REFERENCES

The Causes and predictors of mortality in biopsyproven lupus nephritis: the Sarawak experience

Cheng Lay
  • Clin Kidney J
  • 2018
VIEW 1 EXCERPT

erythematosus

Cheng Lay
  • 2018