Bruton's tyrosine kinase is a key regulator in B-cell development.

@article{Rawlings1994BrutonsTK,
  title={Bruton's tyrosine kinase is a key regulator in B-cell development.},
  author={David J Rawlings and Owen N Witte},
  journal={Immunological reviews},
  year={1994},
  volume={138},
  pages={105-19}
}