Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.

@article{Rawlings1999BrutonsTK,
  title={Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.},
  author={David J Rawlings},
  journal={Clinical immunology},
  year={1999},
  volume={91 3},
  pages={243-53}
}
Genetic data support a role for Btk during the B lineage development transitions regulated by signaling through both the pre-B and the B cell antigen receptors. Dysregulated signaling at each of these transitions can result in failure of these cell populations to proliferate and subsequent cell death. Btk-dependent IP3 production is crucial for maintaining the sustained calcium signal in response to BCR engagement and is likely to regulate a subset of transcriptional events essential for B… CONTINUE READING