Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?

  title={Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?},
  author={Caroline A. Jefferies and Luke A J O'Neill},
  journal={Immunology letters},
  volume={92 1-2},
The discovery of the Toll-like receptors (TLRs) has revolutionised the field of innate immunity. One unresolved question regarding LPS signalling is whether there is a role for tyrosine kinases downstream of the LPS receptor. Studies in mice deficient in Bruton's tyrosine kinase have previously shown that they are defective in their responses to LPS. Further investigation into the role of Btk in LPS signalling has directly implicated Btk downstream of TLR4, both with respect to p38 MAPK… CONTINUE READING
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