Bruton's Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor α Production

@article{Horwood2003BrutonsTK,
  title={Bruton's Tyrosine Kinase Is Required For Lipopolysaccharide-induced Tumor Necrosis Factor α Production},
  author={Nicole J. Horwood and Tara Mahon and John Patrick McDaid and Jamie Campbell and Hiroyuki Mano and Fionula Mary Brennan and David A Webster and Brian M.J. Foxwell},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={1603 - 1611}
}
Lipopolysaccharide (LPS), a product of Gram-negative bacteria, is potent mediator of tumor necrosis factor (TNF)alpha production by myeloid/macrophage cells. Inhibitors capable of blocking the signaling events that result in TNF alpha production could provide useful therapeutics for treating septic shock and other inflammatory diseases. Broad spectrum tyrosine inhibitors are known to inhibit TNF alpha production, however, no particular family of tyrosine kinases has been shown to be essential… CONTINUE READING

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Humoral immunodeficiencies. In Immunology and Allergy Clinics of North America

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