Brugia pahangi and Wolbachia: the kinetics of bacteria elimination, worm viability, and host responses following tetracycline treatment.

@article{Chirgwin2003BrugiaPA,
  title={Brugia pahangi and Wolbachia: the kinetics of bacteria elimination, worm viability, and host responses following tetracycline treatment.},
  author={Sharon R Chirgwin and Jena M. Nowling and Sharon U Coleman and Thomas R. Klei},
  journal={Experimental parasitology},
  year={2003},
  volume={103 1-2},
  pages={16-26}
}
Wolbachia spp., first reported from filariae nearly 30 years ago, have been suggested to contribute to the pathogenesis associated with human filarial infection. Tetracycline has been used to cure filariae of Wolbachia, as a novel means of chemotherapeutic treatment for both ocular and lymphatic filariasis. Tetracycline treatment of L4 or adult Brugia pahangi in vivo resulted in Wolbachia clearance. Less tetracycline was required to clear Wolbachia when treatment began at the L4 stage, compared… CONTINUE READING

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