Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation

@inproceedings{Paul2015BruchpilotAS,
  title={Bruchpilot and Synaptotagmin collaborate to drive rapid glutamate release and active zone differentiation},
  author={Mila M. Paul and Martin Pauli and Nadine Ehmann and Stefan Hallermann and Markus Sauer and Robert J Kittel and Manfred Heckmann},
  booktitle={Front. Cell. Neurosci.},
  year={2015}
}
The active zone (AZ) protein Bruchpilot (Brp) is essential for rapid glutamate release at Drosophila melanogaster neuromuscular junctions (NMJs). Quantal time course and measurements of action potential-waveform suggest that presynaptic fusion mechanisms are altered in brp null mutants (brp(69) ). This could account for their increased evoked excitatory postsynaptic current (EPSC) delay and rise time (by about 1 ms). To test the mechanism of release protraction at brp(69) AZs, we performed… CONTINUE READING
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