Brucella abortus vaccine strain RB51 produces low levels of M-like O-antigen.

@article{Cloeckaert2002BrucellaAV,
  title={Brucella abortus vaccine strain RB51 produces low levels of M-like O-antigen.},
  author={Axel 7 Cloeckaert and Michel Stanislas Zygmunt and Laurence A. Guilloteau},
  journal={Vaccine},
  year={2002},
  volume={20 13-14},
  pages={1820-2}
}
Brucella abortus RB51 is a rough (R) stable vaccine strain used in cattle and is believed to be devoid of O-side chain. We analyzed by use of a panel of monoclonal antibodies (MAbs) directed against seven previously defined O-polysaccharide (O-PS) epitopes the O-chain expression in strain RB51. Two MAbs specific for the C/Y (A=M) and C (M>A) epitopes showed low bindings in ELISA to strain RB51. O-chain expression was further confirmed by Western blot after SDS-PAGE of strain RB51. In particular… CONTINUE READING
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