Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.

@article{Samartino2010BrucellaAI,
  title={Brucella abortus induces the secretion of proinflammatory mediators from glial cells leading to astrocyte apoptosis.},
  author={Clara Garc{\'i}a Samartino and Mar{\'i}a Victoria Delpino and Clara Pott Godoy and Mar{\'i}a Silvia Di Genaro and Karina A Pasquevich and Astrid Zwerdling and Paula Barrionuevo and Patricia A Mathieu and Juliana Cassataro and Fernando Pitossi and Guillermo H Giambartolomei},
  journal={The American journal of pathology},
  year={2010},
  volume={176 3},
  pages={1323-38}
}
Central nervous system (CNS) invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. In this study we present in vivo and in vitro evidence that B. abortus and its lipoproteins activate the innate immunity of the CNS, eliciting an inflammatory response that leads to astrogliosis, a characteristic feature of neurobrucellosis. Intracranial injection of heat-killed B. abortus (HKBA) or outer membrane protein 19 (Omp19), a B. abortus lipoprotein model… CONTINUE READING